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Lanre Morenikeji

Lanre Morenikeji
Lanre Morenikeji
Assistant Professor of Biology

Division of Biological and Health Sciences

Contact Information:
Email: obm3@pitt.edu
Phone: 814-362-5135
Location: 203F Fisher Hall

Degrees and Credentials

Post-Doctoral Fellow
Genomics & Immunology
Rochester Institute of Technology, Rochester, NY
08/2018-12/2019

Ph.D. Animal Genetics & Genomics
Federal University of Technology, Akure, Nigeria
2013 – 2017

Pre-Doctoral Fellow
Animal Genomics & Bioinformatics
Cornell University, Ithaca, NY
2015 – 2016

M.S. Animal Breeding & Genetics
Federal University of Technology, Akure, Nigeria
2009 – 2011

B.S. Animal Production and Health
Federal University of Technology, Akure, Nigeria
2002 – 2008

Short Bio

Primary research interest include; systems immunology, molecular biology and computational genomics.

As a faculty, teaching and research are his main career passions. For several years, Lanre has been dedicated to applying both experimental and computational genomics approaches to understand the underlying mechanism of phenotypic and genotypic differences shaped by the evolutionary forces and elucidating biological pathways of complex trait expression in animals and humans.

Specifically, his research has focused on perturbation of innate immune gene expression due to variations in host-pathogen interactome which could be deployed for disease surveillance and potential diagnostic biomarkers, vaccine production or as drug targets. His current research interests included identification of naturally occurring genome plasticity for disease tolerance, deciphering the role of non-coding RNAs in immune gene regulation, and development of a network-based pipelines to elucidating crosstalk among regulatory elements (such as lncRNA, miRNA and TFs) associated with immune response in infectious disease progression and outcome.

Up till date, He has mentored more than 30 undergraduate students, many of which have also proceeded to either the graduate schools, pursuing careers in all areas of biology or ended up in industries. His goal as a professor is to engage students in real research, working one-on-one with them, providing open access and mentorship, being a positive role model and giving his time and energy to make sure his students succeed in and outside the classroom. This is key to training the next generation of scientists.

Academic Focus

Area of expertise: genomics, functional genomics, epigenetics, immunology, bioinformatics, disease/complex trait expression, transcriptional control, population genomics, genome stability, genome evolution and comparative genomics.

Research, Accomplishments, and Publications

Please see my google scholar or the list below:
Google Scholar

PEER-REVIEWED PUBLICATIONS (* denotes student co-authors)

  1. Oboh MA, Morenikeji OB, Ojurongbe O, Thomas BN. Transcriptomic analyses of differentially expressed human genes, micro RNAs and long-non-coding RNAs in severe, symptomatic and asymptomatic malaria infection. Scientific Reports 2024; 14: 16901
  2. *Taiwo G, *Idowu M, *Sidney T, *Adekunle A, Cervantes AP, Peters SO, Ogunade IM, Morenikeji OB. Characterization of rumen microbiome and immune genes expression of crossbred beef steers with divergent residual feed intake phenotypes, BMC Genomics, 2024; 25, 245
  3. Dari AG, Vahedian M, Kempisty V, Bartosz A, Morenikeji OB, Farzaneh M, Amir A. The Protective Role of miR-125b in Hepatocellular Carcinoma: Unraveling Tumor-Suppressive Mechanisms. Current Molecular Medicine, 2024; 235
  4. Anbiyaee O, Moalemnia A, Ghaedrahmati F, Shooshtari MK, Khoshnam SE, Kempisty B, Halili SA, Farzaneh M, Morenikeji OB. The functions of long non-coding RNA (lncRNA)-MALAT-1 in the pathogenesis of renal cell carcinoma. BMC nephrology, 2023; 24(1), 380.
  5. *Idowu M, *Taiwo GA, *Sidney T, *Eichie F, Morenikeji OB, Pech-Cervantes AA, Ogunade IM. 322 Metabolic Pathway and Rumen Bacterial Taxa Associated with Divergent Residual Body Weight Gain Phenotypes in Beef Cattle, Journal of Animal Science, 2023; 101, 278–279.
  6. *Sidney T, *Taiwo GA, *Idowu M, Pech-Cervantes AA, Ogunade IM, Morenikeji OB. 323 Rumen Fluid Amine/Phenol-Metabolome of Beef Steers with Divergent Residual Feed Intake Phenotype. Journal of Animal Science, 2023; 101, 279–280
  7. *Idowu M, *Ologunagba D, *Taiwo GA, *Sidney TS, *Treon E, *Leal Y, *Eichie F, Morenikeji OB, Pech-Cervantes AA, Ogunade IM. PSIII-10 Hepatic Mrna Expression of Genes Related to Innate and Adaptive Immune Genes in Beef Steers with Divergent Residual Body Weight Gain, Journal of Animal Science, 2023; Pages 384–385.
  8. *Taiwo GA, *Idowu M, *Sidney TS, Morenikeji OB, Ogunade IM. PSII-27 Inflammation- and Immunity-Associated Gene Expression in the Liver and Whole Blood of Crossbred Beef Cattle with Divergent Residual Feed Intake Phenotype, Journal of Animal Science, 2023; 101, 608–609.
  9. Morenikeji OB, Kutchy NA. Role of non-coding RNAs, metabolites, and extracellular vesicles in disease regulation and health. Editorial, Frontiers in Genetics 2023; 14: 1206569
  10. *Idowu M, *Taiwo GA, *Sidney TS, Morenikeji OB, *Cervantes AP, *Estrada-Reyes ZM, Wilson M, Ogunade IM. The differential plasma and ruminal metabolic pathways and ruminal bacterial taxa associated with divergent residual body weight gain phenotype in crossbred beef steers, Translational Animal Science, 2023; txad054
  11. Yousuf S, Yousuf T, Morenikeji OB, Kutchy NA. Phytochemotypic profiling and GCMS Analysis of Viola patrinii, a Himalayan Herb. Journal of Pharmacology and Experimental Therapeutics 2023, 385 (S3) 521
  12. Kutchy NA, Morenikeji OB, Ugur MR, Lesch B, *Memili A. Deciphering sperm functions using biological networks. Biotechnology and Genetic Engineering Reviews 2023; doi: 10.1080/02648725.2023.2168912 
  13. Morenikeji OB, *Metelski JL, *Grytsay A, *Soulas J, Akinyemi MO, and Thomas BN Molecular genotyping reveals mixed bovine and human trypanosomiasis in cattle from West Africa. Veterinary World. 2023; 16: 149–153. 
  14. Akinyemi MO, *Finucan J, *Grytsay A, Osaiyuwu OH, *Adegbaju MS, Ogunade IM, Thomas BN, Peters SO, Morenikeji OB. Molecular Evolution and Inheritance Pattern of Sox Gene Family among Bovidae. Genes. 2022; 13(10):1783 
  15. Oboh MA, Isaac C, Schroeter MN, Morenikeji OB, Amambua-Ngwa A, Meremikwu MM, Thomas BN. Population genetic analysis of Plasmodium falciparum cell-traversal protein for ookinetes and sporozoite among malaria patients from southern Nigeria. Infection Genetics and Evolution 2022; 105:105369 
  16. *Memili A, Kutchy NA, *Braimah OA, Morenikeji OB. Evolutionary conservation of motifs within vanA and vanB of vancomycin resistant enterococci. Veterinary World 2022 15(10): 2407–2413 
  17. Morenikeji OB, *Braimah OA, * Memili A, *Murphy T and Bolaji Thomas. miRNA-target genes interactome associated with heat and immune homeostasis in evolutionarily-adapted cattle. Journal of Immunology 2022; 208 (1) 124.17 
  18. Morenikeji OB, *Adegbaju MS, *Okho OS, *Babalola AE, *Grytsay A, *Braimah OA, Akinyemi MO, Thomas BN. Deciphering inhibitory mechanism of coronavirus replication through host miRNAs-RNA-dependent RNA polymerase (RdRp) interactome. Frontiers in Genetics 2022; 13:973252 
  19. *Taiwo G, *Idowu M, *Sidney T, Morenikeji OB, Ogunade IM. Urine metabolome reveals candidate biomarkers for divergent residual feed intake in beef cattle. URINE 2022; 4:1016 
  20. Yousuf S, Morenikeji OB, Kutchy NA, Singh AP. Elucidating Pharmacological Activities of Volatile Chemotypes in Essential Oil of Morina longifolia. The FASEB Journal, 2022; 36  
  21. *Tucker AR, *Salazar NA, *Ayoola AO, Memili E, Thomas BN, Morenikeji OB. Regulatory network of miRNAs, lncRNAs, transcription factors and target genes associated with immune response in bovine mastitis. Scientific Reports 2021;11, 21899 
  22. Bhalla M, Heinzinger LR, Morenikeji OB, Marzullo B, Thomas BN, Bou Ghanem EN. Transcriptome profiling reveals CD73 and age-driven changes in neutrophil responses against Streptococcus pneumoniae. Infection and Immunity 2021; doi: 10.1128/IAI.00258-21
  23. *Ayoola AO, Zhang B, Meisel RP, Nneji LM, Shao Y, Morenikeji OB, Adeola AC, Dganga S, Roos C, Ogunjemite BG, Okeyoyin AO, Mittermeier RA, Wu D. Population genomics reveals incipient speciation and introgression in the Mona monkey (Cercopithecus mona) of African Guenon. Molecular Biology and Evolution 2021; 38 (8), 876-890; https://doi.org/10.1093/molbev/msaa248
  24. Morenikeji OB, *Bernard K, *Strutton E, *Wallace M and Thomas BN. Evolutionarily conserved long non-coding RNA regulates gene expression in cytokine storm during COVID-19. Frontiers in Bioengineering and Biotechnology 2021; 8, 582953; doi: 10.3389/fbioe.2020.582953
  25. Morenikeji OB, Akinyemi MO, Wheto M, *Ogunshola OJ, Badejo AA, Chineke CA. Breed and sex effects on morphometric parameters of four indigenous cattle in Nigeria. Arch. Zootec 2021; 70 (269): 6-12. 
  26. Morenikeji OB, *Wallace M, *Strutton E, *Bernard K, *Yip E and Thomas BN. Integrative network analysis of predicted miRNA-targets regulating expression of immune response genes in bovine coronavirus infection. Frontiers in Genetics 2020; 11, 584392; doi: 10.3389/fgene.2020.584392
  27. Peters SO, Hussain T, Adenaike AS, Hazzard J, Morenikeji OB, De Donato M, Paul S, Babar M, Yakubu A, Imumorin IG. Evolutionary pattern of interferon alpha genes in Bovidae and genetic diversity IFNAA in the bovine genome. Frontiers in Immunology 2020; 11,580412; doi: 10.3389/fimmu.2020.580412
  28. Morenikeji OB, *Strutton E, *Wallace M, *Bernard K, *Yip E, and Thomas BN. Dissecting transcription factor-target interaction in bovine coronavirus infection. Microorganisms 2020; 8, 1323; doi: 10.3390/microorganisms8091323
  29. *Adegbaju MS, Morenikeji OB, Borrego EJ, Hudson AO, Thomas BN. Differential evolution of α-Glucan Water Dikinase (GWD) in plants. Plants 2020; 9, 1101; https://doi.org/10.3390/plants9091101
  30. Morenikeji OB *Metelski JL, Thomas BN. Significant upregulation of signaling and pro-inflammatory markers indicate adaptation for tolerance in bovine trypanosomosis. Journal of Immunology 2020; 92(1), 7
  31. Morenikeji OB, Ajayi OO, Peters SO, Mujibi FD, De Donato, Thomas BN, Imumorin IG. RNA-seq profiling of skin in temperate and tropical cattle. Journal of Animal Science and Technology 2020; 62:141-158 https://doi.org/10.5187/jast.2020.62.2.141
  32. Morenikeji OB, *Metelski JL, *Hawkes ME, *Capria AL, *Seamans BN, Falade CO, Ojurongbe O, Thomas BN. CD209 and not CD28 or STAT6 polymorphism mediates clinical malaria and parasitemia among children from Nigeria. Microorganisms 2020; 8,158. doi: 10.3390/microorganisms8020158
  33. Morenikeji OB, *Capria AL, Ojurongbe O, Thomas BN. SNP diversity in CD14 gene promoter reveals possible evidence of adaptation footprints in trypanotolerant N'Dama (Bos taurus) but not susceptible White Fulani (Bos indicus) cattle. Genes 2020; 11,112. doi: 10.3390/genes11010112
  34. Morenikeji OB, *Hawkes ME, Hudson AO, Thomas BN. Computational network analysis identifies evolutionarily conserved miRNA-gene interaction potentially regulating immune response in bovine trypanosomiasis. Frontiers in Microbiology 2019; 10:2010 https://doi.org/10.3389/fmicb.2019.02010
  35. Morenikeji OB, Thomas BN. In silico analysis of CD14 molecule reveals significant evolutionary diversity potentially associated with speciation and variable immune response in mammals. PeerJ 2019; 7:e7325 doi: 10.7717/peerj.7325
  36. *Seamans BN, *Pellechio SL, *Capria AL, *Agyingi SE, Morenikeji OB, Ojurongbe O, Thomas BN. Genetic diversity of CD14, CD28, CTLA-4 and ICOS gene promoter polymorphism in African and American sickle cell disease. Human Immunology 2019; pii: S0198-8859(19)30556-7 doi: 10.1016/j.humimm.2019.08.005
  37. Morenikeji OB and Thomas BN. Disease tolerance and immune response in bovine trypanosomiasis is mediated by CD14 promoter gene. Journal of Immunology 2019; 73(1), 17
  38. Morenikeji OB, Akinyemi MO, Wheto M, *Ogunshola OJ, Badejo AA, Chineke CA. Transcriptome profiling of four candidate milk genes in milk and tissue samples of temperate and tropical cattle. Journal of Genetics 2019; 98:25 https://doi.org/10.1007/s12041-019-1060-y
  39. Morenikeji OB, *Ogunshola OJ, Adu OA, Aro SO, Chineke CA. Genotype and sex effects on the performance characteristics of pigs. International Journal of Livestock Production 2019; 10:127-134 https://afribary.com/works/genotype-and-sex-effects-on-the-performance-characteristics-of-pigs
  40. Ajayi OO, Peters SO, De Donato M, Sowande OS, Mujibi FD, Morenikeji, OB, Thomas BN, Adeleke MA, Imumorin IG.  Computational genome-wide identification of heat shock protein genes in the bovine genome. F1000Research 2018; 7: 1504 doi: 10.12688/f1000research.16058.1
  41. Morenikeji OB, *Ogunshola OJ, Wheto M, Adebayo AA, Chineke CA. Variants mining of Kappa casein (K-CN) and Prolactin (PRL) genes among four indigenous cattle breeds in Nigeria. International Journal of Scientific & Engineering Research 2018; 9: 1907 ISSN 2229-5518
  42. Morenikeji OB, *Oghate EB, *Adetunbi AJ, *Ogunshola OJ, Chineke CA. Association of kappa-casein genotype and the linear parameter in two indigenous Bos indicus cattle in Nigeria. Open Journal of Agricultural Science 2018; 1:12 Article Ref. No.: 01201801116
  43. Morenikeji OB, Chineke CA, Adu OA, Aro SO. Genetic correlation and heritabilities of performance traits among three pig genotypes. International Journal of Scientific & Engineering Research 2013; 4(3):120-129 ISSN 2229-5518
  44. Morenikeji OB, Adu OA, Chineke CA. Body weight prediction of three pig genotypes using linear body measurements. Applied Tropical Agriculture 2012; 17 (2):154-159

PEER-REVIEWED ABSTRACTS/CONFERENCE PRESENTATIONS

  1. *Grytsay A, *Saccoh F, *Andrews ND, *Das AA, Morenikeji OB. Bta-mir-2460 and bta-mir-193-2 expression differentially correlate with target receptor molecules in bovine tissue samples. 18th International Congress of Immunology (IUIS), Cape Town, South Africa. November 27–December 2, 2023
  2. Oboh M, Morenikeji OB, Ojurongbe O, Thomas B. Evolutionarily-conserved non-coding RNA to the rescue of malaria drug resistance. 18th International Congress of Immunology (IUIS), Cape Town, South Africa. November 27–December 2, 2023
  3. *Taiwo GA, *Idowu M, *Sidney T, *Eichie F, Morenikeji OB, Ogunade IM. Dietary Fenugreek Seed Extract Improves Dry Matter Intake, Apparent Total Tract Nutrient Digestibility, and Alters Whole Blood Transcriptome of Holstein Dairy Heifers. ASAS/ CSAS/ WSASAS. Albuquerque, New Mexico. July 16-20, 2023.
  4. *Idowu M, *Ologunagba D, *Taiwo GA, *Sidney T, *Treon E, *Leal Y, *Eichie F, Morenikeji OB, Ogunade IM. Hepatic mRNA expression of genes related to innate and adaptive immune genes in beef steers with divergent residual body weight gain. ASAS/ CSAS/ WSASAS. Albuquerque, New Mexico. July 16-20, 2023.
  5. *Idowu M, *Taiwo GA, *Sidney T, *Treon E, *Ologunagba D, *Leal Y, *Eichie F, Morenikeji OB, Ogunade IM. Effects of rumen-bypass protein supplement on growth performance, hepatic mitochondrial function, and immune gene expression of beef steers with divergent residual feed intake phenotype. ASAS/ CSAS/ WSASAS. Albuquerque, New Mexico. July 16-20, 2023.
  6. Grytsay A, *Young GE, *Andrews ND, *Bauer KB, Morenikeji OB. Signature of microRNAs correlates with differential target gene expression in tissue samples. Annual Research Symposium, Regional Science Consortium, Erie, PA. November 2-4, 2022 
  7. *Andrews ND, *Grytsay A, *Young GE, *Bauer KB, Morenikeji OB. The role of micro RNAs during cellular response to heat stress. Annual Research Symposium, Regional Science Consortium, Erie, PA. November 2-4, 2022 
  8. Morenikeji OB, *Braimah OA, * Memili A, *Murphy T, Thomas BN. miRNA-target genes interactome associated with heat and immune homeostasis in evolutionarily adapted cattle. The Annual Meeting of The American Association of Immunologists, IMMUNOLOGY2022, Portland, Oregon. May 6-10, 2022  
  9. *Memili A, Kutchy NA, Morenikeji OB. Unveiling evolutionary pathways of antibiotic resistomes to achieve global one health. Annual Meeting of the American Association for the Advancement of Science 2022, Washington DC, February 17-20, 2022 
  10. Morenikeji OB, *Tucker AR, *Salazar NA, *Ayoola AO, Thomas BN. Regulatory network of miRNAs, lncRNAs and target genes associated with immune response in bovine mastitis. The Annual Meeting of The American Association of Immunologists, Virtual IMMUNOLOGY2021. May 10-15, 2021
  11. *Wallace M, *Strutton E, *Bernard K, *Yip E, Morenikeji OB. Evolutionary elucidation of conserved miRNA-targets potentially regulating immune gene expression in bovine coronavirus infection. Annual Biomedical Research Conference for Minority Students (ABRCMS), The Virtual Experience. November 9-13, 2020.
  12. *Strutton E, *Wallace M, *Bernard K, *Yip E, Morenikeji OB. Identification of potential transcription factor-target interaction in bovine coronavirus infection. Annual Biomedical Research Conference for Minority Students (ABRCMS), The Virtual Experience. November 9-13, 2020.
  13. *Bernard K, *Yip E, *Strutton E, *Wallace M, Morenikeji OB. Characterizing possible type I interferon regulators in SARS-CoV-2 infection. Annual Biomedical Research Conference for Minority Students (ABRCMS), The Virtual Experience. November 9-13, 2020.
  14. * Metelski JL, * Hawkes ME, Morenikeji OB, Thomas BN. Extensive interethnic diversity of the CD36 (rs3211938) gene polymorphism is associated with clinical malaria but not disease covariates. Annual Biomedical Research Conference for Minority Students (ABRCMS), Anaheim, CA. November 13-16, 2019.
  15. * Hawkes ME, * Metelski JL, Morenikeji OB, Thomas BN. Genomic dissection of trypanosome internal transcribed spacer (ITS)-1 gene in disease-tolerant cattle. Annual Biomedical Research Conference for Minority Students (ABRCMS), Anaheim, CA. November 13-16, 2019.
  16. Morenikeji OB, Thomas BN. In silico network analysis reveals significantly conserved miRNA-gene interactions during bovine trypanosomosis. 22nd Annual Upstate New York Immunology Conference, Cooperstown, NY. October 27-30, 2019
  17. Morenikeji, OB, *Capria AL, *Pellechio SL, Thomas BN. SNP density at CD14 gene promoter activates a higher downstream expression which mediate disease tolerance and immune response in bovine trypanosomiasis. UNYTE Translational Genomics and Proteomics. An Un-Meeting, Rochester, NY. March 13, 2019
  18. Purwantara B, Morenikeji OB, Duryadi D, Rosyada Z, Indriastuti R, Lestari CT, Satrio F, Memili E. Genomic diversity of native cattle breeds in Indonesia. 27th International Conference on Plant and Animal Genomes, San Diego, CA. January 12 – 16, 2019
  19. Morenikeji OB, *Oghate EB, *Adetunbi AJ, *Ogunshola OJ, Chineke CA. Identification of kappa-casein genotype in two indigenous Nigerian cattle. Proceedings of the 7th Animal Science Association of Nigeria-Nigerian Institute of Animal Science (ASAN-NIAS) Joint Annual Meeting, September 9th-13th, 2018; Ilorin. Pp: 140 – 143.
  20. Morenikeji OB, Ajayi OO, Akinyemi MO, Peters SO, Mujibi FD, Wheto M, Ikeobi CON, Thomas BN. Imumorin IG. Comparative expression analysis of heat-adaptation candidate genes in thermoregulatory tissues of temperate and tropical cattle. 25nd International Conference on Plant and Animal Genomes, San Diego, CA. January 14 – 18. 2017.

HONORS & AWARDS

  • 2022 American Association of Immunologists (AAI) Early Career Faculty Award
  • 2021 American Association of Immunologists (AAI) Minority Scientist Award
  • 2020 Judges Travel Award, Annual Biomedical Research Conference of Minority Students 
  • 2020 American Association of Immunologist (AAI) Travel Award 
  • 2019 Judges Travel Award, Annual Biomedical Research Conference of Minority Students 
  • 2019 American Association of Immunologist (AAI) Travel Award 
  • 2018 - 2019 American Association of Immunologist Career Development Fellowship
  • 2018 Judges Travel Award, Annual Biomedical Research Conference of Minority Students 
  • 2015 - 2016 Tertiary Education Trust Fund (TETFund) Visiting Fellowship of the Federal Republic of Nigeria to Cornell University, Ithaca, NY